ABSENCE OF SEXUAL DEVELOPMENT

ABSENCE OF SEXUAL DEVELOPMENT
Absence of sexual development is absence of menarche, absence of development of pectoral glands in age more than 16 years old.

Reason of this pathology is aplasia of gonads or violation of their development at which active hormone-producting tissue of ovaries is absent functionally. Sexual development does not come for girls to which by any testimony the delete of ovaries was conducted under age 8-10 years old. By other reason of absence of sexual development the defect of development of sexual glands, causedby dysgenesia of gonads, is genetically conditioned. Dysgenesia of gonads is rare pathology, with frequency 1 on 10 - 12 000 new-born.

Reason of development of dysgenesia of gonads is chromosomal violations as one loss of Х chromosome or its part. More frequent in all there are four clinical forms of dysgenesia of gonads: typical, or classic (syndromeTurner), effaced, clean and mixed.



Climax by woman and men

Menopause is the appropriate stage of individual development of man, transitional period from maturity to old age, which is accompanied the loss of reproductive function. A climax can be physiology or pathological. Middle ages of offensive of climax – 49-51 year, for women - 45-55 years, for men - 47-60 years. Duration of menopause – 2-5 years. Frequency of pathological motion of menopause is 25-50%.

Climacteric syndrome, or a pathological climax is an aggregate of endocrine-vegetative violations which are formed for some people during climacteric hormonal alteration. A deciding value has a presence of premorbid background - presence of stress factors, psycho-emotional or sexual violations, sharp or chronic diseases of СNS, internal organs, genitals.

Pathogeny of climacteric syndrome consists in the "senescence of hypothalamus", violation of functioning of homeostatic centers, located in hypothalamus and limbic system which results in disfunction of hypophysis and sexual glands.